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Increase in etoposide-induced topoisomerase II-mediated DNA breaks after cell synchronization induced by low doses of methotrexate

โœ Scribed by Aurelio Lorico; Germana Rappa; Mauro Boiocchi; Fabio Anzanello; Maurizio D'Incalci

Book ID
115780488
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
184 KB
Volume
37
Category
Article
ISSN
0006-2952

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Increase in topoisomerase-II-mediated dn
Increase in topoisomerase-II-mediated dna breaks and cytotoxicity of VP16 in human U937 lymphoma cells pretreated with low doses of methotrexate
โœ Aurelio Lorico; Mauro Boiocchi; Germana Rappa; Soumitra Sen; Eugenio Erba; Mauri ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 619 KB

Pre-treatment with low, non-toxic concentrations ( 0 . 0 4 ~~) of methotrexate (MTX) for I6 hr increased etoposide (VP 16)induced growth inhibition and cytotoxicity in the U937 human histiocytic lymphoma cell line. VP I6 cytotoxicity was significantly potentiated when the drug was given for 2 hr imm