It was previously reported that silkworm hemolymph (SH) inhibits apoptosis and increases the production of recombinant human erythropoietin (EPO) in Chinese hamster ovary (CHO) cells. The apoptosisinhibiting component in SH is a member of 30K protein family. In this study, the CHO cell line producin
โฆ LIBER โฆ
Increase in efficiency of media utilization for recombinant protein production in Chinese hamster ovary culture through dilution
โ Scribed by Shreya Thombre; Mugdha Gadgil
- Publisher
- Portland Press
- Year
- 2011
- Tongue
- English
- Weight
- 318 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0885-4513
- DOI
- 10.1002/bab.9
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When three recombinant Chinese hamster ovary (rCHO) cell lines, CHO/dhfr-B22-4, CS13-1.00\*, and CS13-0.02\*, were cultivated in hyperosmolar media resulting from NaCl addition, their specific foreign protein productivity increased with medium osmolality. However, due to a simultaneous suppression o