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Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus

✍ Scribed by Patrick Blanco; Vincent Pitard; Jean-François Viallard; Jean-Luc Taupin; Jean-Luc Pellegrin; Jean-François Moreau

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
271 KB
Volume
52
Category
Article
ISSN
0004-3591

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## Abstract ## Objective Analysis of peripheral B cell subsets in patients with systemic lupus erythematosus (SLE) has provided evidence of specific alterations, such as an expansion of CD27++ plasma cells/blasts and transitional B cells. However, memory B cells in lupus have not been thoroughly i