## Abstract Hyposmia is one of the most prevalent symptoms of Parkinson's disease. It may occur even before the motor symptoms start. To determine whether the olfactory dysfunctions, like the motor symptoms, are associated with a loss of dopamine, the number of dopaminergic cells in the olfactory b
Increase in a focal population of juxtaglomerular cells in the olfactory bulb associated with early learning
β Scribed by Cynthia C. Woo; Michael Leon
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 907 KB
- Volume
- 305
- Category
- Article
- ISSN
- 0021-9967
No coin nor oath required. For personal study only.
β¦ Synopsis
Young rats learn to approach an odor that had been experienced in the presence of reinforcing tactile stimulation. Subsequent presentation of the conditioned odor also evokes an enhanced focal uptake of 2-deoxyglucose (2-DG) in the glomerular layer of the olfactory bulb, and the glomerular-layer width of such foci increases in conditioned pups. In the present study, we determined whether an increase in the glomerular-layer cell population contributes to this structural and functional change. We therefore counted and measured glomerular-layer cells in Nissl-stained sections from focal regions of radiolabeled 2-DG uptake. While cell size did not differ between groups, conditioned pups had a 19% increase in the number of glomerular-layer cells associated with the 2-DG foci compared to controls. The increase in cell number may contribute to the enhanced 2-DG uptake in glomerular-layer foci.
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