Incorporation of titanium into calcium silicate improved their chemical stability and biological properties

✍ Scribed by Chengtie Wu; Yogambha Ramaswamy; Andhika Soeparto; Hala Zreiqat

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 581 KB
• Volume: 86A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.31623

✦ Synopsis

Abstract

Calcium silicate (CaSiO~3~) is regarded as a potential bioactive material. However, its poor chemical stability and cytocompatibility limits its biological applications. The aim of this study is to incorporate Titanium (Ti) into CaSiO~3~ to produce a ceramic with improved chemical stability and biological properties. Sphene (CaTiSiO~5~) ceramics were prepared by sintering sol–gel‐derived CaTiSiO~5~ powder compacts and their chemical stability was assessed by measuring the ions released and weight loss after soaking CaTiSiO~5~ in simulating body fluid for 1, 3, 7, and 14 days. Results indicated that CaTiSiO~5~ has a significantly improved chemical stability, compared with CaSiO~3~. The ability of CaTiSiO~5~ ceramics to support human bone‐derived cells (HBDC) attachment, proliferation, and differentiation was assessed using scanning electron microscopy, MTS, and alkaline phosphatase activity assays, respectively. CaTiSiO~5~ ceramics supported HBDC attachment and significantly enhanced their proliferation and differentiation, compared with CaSiO~3~ ceramics. Taken together, this study demonstrates that the newly developed CaTiSiO~5~ ceramics possess excellent chemical stability and bioactivity, suggesting their potential use in skeletal tissue regeneration and as coating onto currently available orthopedic/dental implants. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008