Incorporation of Peptide Isosteres into
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Melissa M. Vasbinder; Elizabeth R. Jarvo; Scott J. Miller
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Article
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2001
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John Wiley and Sons
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English
โ 130 KB
Olefinic analogues of effective peptide-based catalysts for the kinetic resolution of functionalized racemic secondary alcohols have been synthesized. The isosteric replacement of the peptide amide bond in 1 with an (E)-alkene to form 2 has enabled the evaluation of the kinetic role of particular am