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Incorporation of L-[U-14C]-β-phenylalanine into the lignan podophyllotoxin

✍ Scribed by D.C. Ayres

Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
162 KB
Volume
10
Category
Article
ISSN
0040-4039

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Chiral synthesis of L-[14C]phenylalanine
Chiral synthesis of L-[14C]phenylalanine and its incorporation into the renin inhibitor PD 132002
✍ Helen T. Lee; James L. Hicks; Donald R. Johnson 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 327 KB 👁 1 views

## Abstract [1S‐(1R\*,2S\*,3R\*)]‐3‐[[1‐(Cyclohexylmethyl)‐2,3‐dihydroxy‐5‐methylhexyl]‐amino]‐N‐[N‐(4‐morpholinosulfonyl)‐L‐ phenylalanyl]‐3‐oxo‐DL‐alanine methyl ester (PD 132002) was found to be a renin inhibitor and thus potentially useful for the treatment of hypertension. This peptidomimetic