Incorporation of Inhibin-A in Second-Trimester Screening for Down syndrome: In Reply
โ Scribed by Peter Benn; M Fang; J.F.X Egan
- Book ID
- 117191901
- Publisher
- Lippincott Williams and Wilkins
- Year
- 2003
- Tongue
- English
- Weight
- 56 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0029-7844
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๐ SIMILAR VOLUMES
Initial studies of immunoreactive inhibin using a commercial assay have shown levels to be increased in three second-trimester series of maternal samples from Down's syndrome-affected pregnancies. This assay detected non-specifically all forms of circulating inhibin, dimeric and free alpha subunits,
Case-control studies in the Caucasian population showed that maternal serum inhibin-A is elevated in Down syndrome pregnancies and may be a useful second-trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). Data in the Asian population are lacking. We meas
To assess the value of inhibin A as an additional second-trimester maternal serum marker of Down's syndrome we studied 56 affected and 280 unaffected pregnancies matched for gestational age. The median level in the cases was 1.62 multiples of the gestation-specific median (MOM) in the controls, with