Incorporation of an Artificial Receptor into a Native Protein: New Strategy for the Design of Semisynthetic Enzymes with Allosteric Properties

Incorporation of artificial receptors in

Incorporation of artificial receptors into a protein/peptide surface: A strategy for on/off type of switching of semisynthetic enzymes

✍ Itaru Hamachi; Jun-ichi Watanabe; Ryoji Eboshi; Takashi Hiraoka; Seiji Shinkai 📂 Article 📅 2000 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 536 KB

Recent developments in new bioorganic methodologies have greatly facilitated the site-specific incorporation of non-natural amino acids into the protein framework. It is now desirable for chemists to explore promising concepts based on chemistry for regulation and extension of functions of naturally