𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Incomplete Fmoc deprotection in solid-phase synthesis of peptides

✍ Scribed by LARSEN, BJARNE DUE ;HOLM, ARNE

Book ID
111901307
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
978 KB
Volume
43
Category
Article
ISSN
0367-8377

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Improved acidolytic deprotection conditi
Improved acidolytic deprotection conditions for the Fmoc-based solid-phase synthesis of thioxo peptides
✍ Julia H Miwa; Laura A Margarida; Ann E Meyer πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 62 KB

The acid-mediated cleavage of a synthetic thioxo peptide was monitored using deprotection cocktails with varying concentrations of TFA. Thioxo peptides are acid labile, undergoing cleavage at the amide linkage immediately following the thioamide linkage in the sequence. This acid lability makes Fmoc

Pseudoproline Dipeptides in Fmoc Solid-P
Pseudoproline Dipeptides in Fmoc Solid-Phase Peptide Synthesis
✍ Barbara Doerner; Rene Steinauer; Sophie Barthelemy; Peter D. White πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons βš– 8 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

One-pot full peptide deprotection in Fmo
One-pot full peptide deprotection in Fmoc-based solid-phase peptide synthesis: methionine sulfoxide reduction with Bu4NBr
✍ Lorena Taboada; Ernesto NicolΓ‘s; Ernest Giralt πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 68 KB

The reduction of methionine sulfoxide with Bu 4 NBr in TFA is reported. The use of this reagent in conjunction with Fmoc chemistry-based acidolytic cocktails and the short reaction times that are needed for sulfoxide reduction (5 min) are the main advantages of this method, which is compatible with