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Incomplete correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin hepatotoxicity with Ah phenotype in mice

✍ Scribed by J.B. Greig; J.E. Francis; S.J.E. Kay; D.P. Lovell; A.G. Smith


Book ID
113206359
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
772 KB
Volume
74
Category
Article
ISSN
0041-008X

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Ah receptor for 2,3,7,8- tetrachlorodibe
✍ Denison, Michael S. ;Okey, Allan B. ;Hamilton, Joshua W. ;Bloom, Stephen E. ;Wil πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 642 KB

Aryl hydrocarbon hydroxylase (AHH, cytochrome P1-450) is induced in chick liver very early during embryonic development if embryos are treated with 3-methylcholanthrenetype compounds such as 3,4,3'4'-tetrachlorobiphenyl. In mammals, AHH induction is known to be mediated by the Ah receptor. Liver fro