Inclusion complexes between β-cyclodextrin and β-benzyloxy-α-propionic derivatives of paramagnetic DOTA- and DPTA-Gd(III) complexes

✍ Scribed by Silvio Aime; Mauro Botta; Maurizio Panero; Maurizio Grandi; Fulvio Uggeri

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 375 KB
• Volume: 29
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1260290910

✦ Synopsis

Abstract

The addition of β‐cyclodextrin to a solution containing β‐benzyloxy‐α‐propionic‐substituted DOTA‐ and DTPA‐Gd(III) complexes leads to the formation of inclusion compounds whose equilibrium constants have been determined by NMR titrations. The main effect associated with the formation of this ‘host‐uest’ interaction is a marked elongation of the molecular reorientational time, τ~r~, which in turn results in increased solvent proton relaxation rates.