Inclusion complexation of warfarin withβ-cyclodextrins and its influence on absorption kinetics of warfarin in rat
✍ Scribed by O. Karadaĝ; E. Gök; I. Serdar Ates; Ö. Kiran; A. Bozkurt
- Publisher
- Springer Netherlands
- Year
- 1994
- Tongue
- English
- Weight
- 634 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0923-0750
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Cyclodextrins are a group of cyclic oligosaccharides with a ring, basket-like structure. These compounds are able to include several kinds of molecules into their internal cavity, leading to important modiÐcations of the properties of the guest compound. The interaction between b-cyclodextrin and t
Chlorpromazine is an antipsychotic agent with poor aqueous solubility. Complexation with SBE 7 -b-CD can aid intravenous delivery through increasing the apparent solubility of chlorpromazine. However, chlorpromazine has also been known to self-associate. This selfassociation can influence its capaci