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Inclusion complexation of prostaglandin f2α with γ-Cyclodextrin in solution and solid phases

✍ Scribed by Kaneto Uekama; Fumitoshi Hirayama; Akihiko Fujise; Masaki Otagiri; Kohji Inaba; Hazime Saitô

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
342 KB
Volume
73
Category
Article
ISSN
0022-3549

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✦ Synopsis

A solid complex of prostaglandin F h (dinoprost) with y-cyclodextrin in a molar ratio of 1:1 was obtained on the basis of the Bs-type phase solubility diagram. The mode of interaction in the solid state was studied by powder X-ray diffractometry, thermal analysis, and carbon-13 cross polarization/magic angle spinning nuclear magnetic resonance (W-CP/MAS-NMR) spectrometry. The X-ray diffraction and NMR data suggested that prostaglandin Fzu is included in the cylindrical channels formed by coaxial alignment of y-cyclodextrin molecules to give a channel type structure. Dissolution and thermal behaviors of the prostaglandin F*,-y-cyclodextrin complex were examined and compared with the drug itself. The result indicated that the y-cyclodextrin complex may have great utility as a rapidly dissolving form of prostaglandin F s ~ with improved thermal stability.

Keyphrases Prostaglandin Fa,-inclusion complex with y-cyclodextrin, solution and solid phases, solubility, dissolution behavior 0 y-Cyclodextrin-inclusion complex with prostaglandin Fk, solution and solid phases, solubility, dissolution behavior 0 Solubility-prostaglandin Fk-y-cyclodextrin inclusion complex, dissolution behavior 0 Dissolution-prostaglandin Fz,-y -cyclodextrin complex, solubility

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