INCLUSION COMPLEXATION OF CYCLOBIS(PARAQUAT-p-PHENYLENE) AND RELATED CYCLOPHANE DERIVATIVES WITH SUBSTITUTED AROMATICS: COOPERATIVE NON-COVALENT CAVITY AND EXTERNAL INTERACTIONS
✍ Scribed by René Castro; Pablo D. Davidov; Kaipeuchery A. Kumar; Alan P. Marchand; Jeffrey D. Evanseck; Angel E. Kaifer
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 265 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0894-3230
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✦ Synopsis
The cooperative nature of non-covalent interactions which give rise to inclusion complexes involving cyclobis(paraquatp-phenylene), 1 4+ , and related cyclophane derivatives, 2 4+ -4 4+ , with substituted 1,4-phenyl and 4,4Ј-biphenyl guests has been studied by spectroscopic techniques and ab initio and semiempirical molecular orbital methods. Inclusion complex formation and stability are primarily determined by the combination of two main interaction modes involving aromatic stacking of the guest within the cyclophane cavity and external interactions between guest side arms and the exterior of the cyclophane. A balance between cavity and external forces results in supramolecular association and is shown to change depending upon the functionality and substitution of the guest. Cavity binding was probed using 1,4-phenyl and 4,4Ј-biphenyl guests, where for the 1,4-phenyl guests the primary basis for energy stabilization with 1 4+ is found to be short-range stabilizing electrostatic forces complemented by small amounts of polarizability and charge-transfer. In contrast, the cavity binding between substituted 4,4Ј-biphenyl guests and 1 4+ is determined by almost equal contributions of polarizability and electrostatics. The effect of solvent is shown to have only a small effect on the computed geometry of 1 4+ complexes, but its impact upon binding energies is substantial. The first solvation shell of the cyclophanes is computationally approximated by 12 acetonitriles and satisfies the requirements of the 16 relatively acidic protons on the bipyridinium groups. Good correlations between the computed (with solvation) and experimental 1 4+ binding energies are found. The degree of linear correlation improves substantially when the comparison between computed and experimentally observed binding energies is restricted to structurally similar (number of aromatic rings, number of substituents and position of substitution) molecular guests. Furthermore, computed molecular properties, such as polarizability, maximum hardness, softness and electronegativity of the isolated guests, correlate well with 1 4+ binding energies based upon the same requirement of guest similarity. The non-covalent forces associated with the external cyclophane interactions were studied with guest molecules built from symmetrical 1,4-extensions of hydroquinone composed of aliphatic or ethyleneoxy side arms. In particular, side arm length and functionality, and the position and type of heteroatoms along the chain, were systematically varied to define the external interactions between the guest side arms and different host cyclophanes. Specifically, the ethyleneoxy linkages are shown to provide a large chelate and cooperative effect which direct the binding with 1 4+ . In order to probe further the special geometric and electronic character of 1 4+ , we have synthesized and tested a new supramolecular host, 2 4+ , similar to 1 4+ but where a pentacycloundecane unit replaces one of the xylyl groups. Both experimental and computed data on the new host emphasize the ideal geometry and electronic nature of the 1 4+ molecular receptor for aromatic guests. The inclusion complexes discussed in this paper are important not only because they, or similar entities, are the main components of