Including receptor flexibility and induced fit effects into the design of MMP-2 inhibitors

✍ Scribed by Jacob D. Durrant; César Augusto F. de Oliveira; J. Andrew McCammon

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 469 KB
• Volume: 23
• Category: Article
• ISSN: 0952-3499
• DOI: 10.1002/jmr.989

✦ Synopsis

Abstract

Matrix metalloproteinases (MMPs) comprise a class of flexible proteins required for normal tissue remodeling. Overexpression of MMPs is associated with a wide range of pathophysiological processes, including vascular disease, multiple sclerosis, Alzheimer's disease, and cancer. Nearly all MMP inhibitors have failed in clinical trials, in part due to lack of specificity. Due to the highly dynamic molecular motions of the MMP‐2 binding pockets, the rational drug design of MMP inhibitors has been very challenging. To address these challenges, in the current study we combine computer docking with molecular dynamics (MD) simulations in order to incorporate receptor‐flexibility and induced‐fit effects into the drug‐design process. Our strategy identifies molecular fragments predicted to target multiple MMP‐2 binding pockets. Copyright © 2009 John Wiley & Sons, Ltd.