Incidence of spontaneous neoplasms in breeding and retired breeder BALB/cCr mice throughout the natural life span
✍ Scribed by Robert L. Peters; Louise S. Rabstein; Gerard J. Spahn; Russell M. Madison; Robert J. Huebner
- Book ID
- 102865775
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- French
- Weight
- 689 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Large populations (approximately 1,300 from weaning to 10 months and 4,500 at 10 to 12 months of age) of BALB/cCr mice were observed throughout the remainder of their natural life span to determine the age‐specific incidence of various spontaneous neoplasms. Over 2,000 mice were necropsied and their tissues examined microscopically. Neoplasms of all types were rare prior to 1 year of age, but an early life (1‐6 months) “peak” of acute lymphocytic leukemia was noted. The incidence of lymphatic neoplasms increased until about 24 months of age and then declined. The incidence of other types of tumor, including reticulum cell neoplasms, mammary and other epithelial tumors, mesenchymal tumors (non‐hematopoietic) and benign tumors increased progressively with increasing age. Mammary tumors, myoepitheliomas, hemangioendotheliomas and fibrosarcomas were the most prevalent solid tumor malignancies. Reticulum cell neoplasms were the most frequent malignant neoplasms of the hematopoietic system. Pulmonary alveologenic and adrenocortical adenomas were the most common tumors among those classified histologically as benign.