Incidence of second primary malignancies after a malignant tumor in childhood a population-based survey in Piedmont (ITALY)

✍ Scribed by Corrado Magnani; Benedetto Terracini; Luca Cordero di Montezemolo; Gabriele Gallone; Lia Luzzatto; Maria Luisa Mosso; Guido Pastore; Paolo Rosso

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 534 KB
• Volume: 67
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19960703)67:1<6::aid-ijc2>3.0.co;2-0

✦ Synopsis

We have studied the frequency of second primary malignancies (SPM) among the 2,328 children registered in 1967-1989 at the Childhood Cancer Registry of Piedmont, the largest population-based childhood cancer registry in Southern Europe. Since the population of Piedmont is not sewed by a conventional cancer registry covering all ages, SPMs were identified through a number of ad hoc surveys within a variety of sources. Eighteen SPM (all histologically diagnosed) were observed after a thorough survey conducted in the oncological departments in Piedmont and after a postal questionnaire addressed to general practitioners. Death certificates were also examined. The crude incidence rate was I 16.5 per 100,000 person-years. Risk was higher among children whose first malignancy was diagnosed more recently (SIR = 9.8 for diagnoses in 1983-1 989 vs. 4.5 for diagnoses in 1967-1974). The same tendency was confirmed in analyses restricted to children in whom leukemia was diagnosed as the first cancer. Clinical data regarding the treatment of the first malignancy were available for I 6 children out of I 8 I5 had received chemotherapy and I2 radiotherapy (9 SPM originated in the irradiation field). The interest of measuring the risk of SPM on a population basis (and not only in clinical series) and the advantage of close cooperation between epidemiologists and clinical oncologists are underlined.