Incidence of parenchymal liver diseases in Denmark, 1981 to 1985: Analysis of hospitalization registry data
✍ Scribed by Thomas P. Almdal; Professor Thorkild I. A. Sørensen
- Book ID
- 102850828
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 594 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
The sex-specific and age-specific incidence rates of the major parenchymal liver diseases in a North European population were estimated using a computerized registry of all admissions to somatic hospitals in Denmark.
The incidence was calculated by counting all incident cases of these diseases reported to the registry in the 5-yr period 1981 to 1985 and dividing the number of cases by the number of person-years at risk in this period.
The incidence rates (per million person-years) were for men and women, respectively: infectious hepatitis, 109 and 71; toxic hepatitis, 19 and 22; chronic hepatitis, 27 and 29; alcoholic cirrhosis, 190 and 85; nonalcoholic nonbiliary cirrhosis, 110 and 82; primary biliary cirrhosis, 4 and 14. The pattern of the age-specific incidence rates was similar in men and women in infectious hepatitis, alcoholic cirrhosis, nonalcoholic nonbiliary cirrhosis and primary biliary cirrhosis. Toxic and chronic hepatitis had a higher incidence in women than in men only in older age groups. The incidence of idiopathic hemochromatosis, Wilson's disease, secondary biliary cirrhosis, portal vein thrombosis and Budd-Chiari's syndrome were less than four in both sexes. (HEPATOLOGY 1991;13:650-655.)
As apparent from Vierling's review in 1984 (1) and from several textbooks in hepatology (2-4)' a general lack of knowledge of the incidence of parenchymal liver diseases exists. Studies of the occurrence of acute liver diseases are based on physicians' reports to specific registers on contagious diseases or side effects of drugs (5, 6). Most studies of the occurrence of chronic liver diseases are derived from either autopsy or mortality figures (7-10). A few studies estimate morbidity from hospital admission rates without taking into account readmissions (3, 11). True incidence studies have only been reported for alcoholic and nonalcoholic cirrhosis in Baltimore, MD, and Birmingham, UK (12,13). On the