Incidence of osteosarcoma, chondrosarcoma and Ewing's sarcoma in east Denmark: Reverse male to female ratio in osteosarcoma

Involvement of P-glycoprotein and MRP1 i

Involvement of P-glycoprotein and MRP1 in resistance to cyclic tetrapeptide subfamily of histone deacetylase inhibitors in the drug-resistant osteosarcoma and Ewing's sarcoma cells

✍ Takamitsu Okada; Kazuhiro Tanaka; Fumihiko Nakatani; Riku Sakimura; Tomoya Matsu 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 399 KB

## Abstract Despite recent improvements in multimodal therapies for osteosarcoma (OS) and Ewing's family of tumors (EFTs), the prognosis of relapsed cases remains very poor because of the resistance to chemotherapy. Histone deacetylase inhibitors (HDACIs), including members of the cyclic tetrapepti