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Incidence of hyperthyroidism after unrelated donor allogeneic stem cell transplantation

✍ Scribed by Jolanta B. Perz; David Marin; Richard M. Szydlo; Chrissy Giles; Eduardo Olavarria; Graham Williams; Jane F. Apperley

Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
98 KB
Volume
31
Category
Article
ISSN
0145-2126

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✦ Synopsis

We report on three patients who developed overt thyrotoxicosis after volunteer unrelated donor bone marrow transplantation for Philadelphia chromosome positive chronic myeloid leukemia shortly after the onset of chronic graft versus host disease. In all three cases, the etiology of hyperthyroidism is likely to be a combination of toxic factors and an immune process. Systematic evaluation of thyroid function tests in 97 unrelated allograft recipients from our center who survived at least 100 days from stem cell or bone marrow transplantation for hematological diseases gave a rate of overt thyrotoxicosis at 3.1% in this cohort.

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## Abstract Allogeneic hematopoietic stem cell transplantation (SCT) is a potentially curative treatment for patients with myelodysplastic syndrome (MDS). Relapses after transplantation however, are not uncommon and are usually due to re‐emergence of a recipient derived, neoplastic, stem cell clone