𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Incidence of hepatitis A virus (HAV) infection in rural Liberia

✍ Scribed by Alfred M. Prince; Betsy Brotman; Linda Richardson; Tim White; Nancy Pollock; Janet Riddle

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
459 KB
Volume
15
Category
Article
ISSN
0146-6615

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✦ Synopsis

To provide background for future hepatitis A vaccine trials, sera were collected from 0to 4-year-old Liberian infants and their mothers on two occasions an average of 14.75 months apart and tested for antibody to hepatitis A virus (anti-HAV) .

The prevalence of anti-HAV rose from 2.5% in infants 0-6 months of age to 70% in children 3-4 years of age and did not differ between male and female infants.

The annual incidence of new infections was slightly lower in the first year of life (35%) than in the subsequent 3 years, when it averaged 45%. The presence of HBV infection did not affect the incidence of HAV seroconversion. No clinical hepatitis was recognized in the subjects who seroconverted. Dual hepatitis A and B virus infection were observed; these were all clinically inapparent.

The extraordinary incidence of HAV infection documented in the present study offers an opportunity for vaccine efficacy trials requiring minimal numbers of subjects.

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