Incidence of experimental fascioliasis on hepatic disposition of [3h]tetracycline and [14c]rafoxanide in rats

✍ Scribed by P. Galtier; G. Larrieu; M. Franc

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 455 KB
• Volume: 74
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600740921

✦ Synopsis

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Tetracycline and [~arbonyl-'~C]rafoxanide were injected intravenously into anesthetized controls and rats in which experimental fascioliasis had been induced by 20 Fasciola hepatica metacercariae. The biliary excretion (1 and 3 h, respectively) of the radioactivity consisted of -4% of the administered dose. In 4-week infested rats, biliary excretion of [3H]tetracycline and hepatic levels of radioactivity were decreased, whereas bile flow did not vary and plasma clearance of the antibiotic was significantly decreased in comparison with control animals. These differences could be the result of the fascioliasisinduced decrease in the hepatic uptake of tetracycline and the limited active transport for its output into bile canaliculi. No change in ['4C]rafoxanide disposition was shown in infested rats.