Recent progress in research on drug-induced liver injury (DILI) has been determined by key developments in two areas. First, new technologies allow the identification of genetic risk factors with improved sensitivity, specificity, and efficiency. Second, new mechanistic concepts of DILI emphasize th
Incidence of drug-induced liver injury in medical inpatients
โ Scribed by Yvonne Meier; Marzia Cavallaro; Malgorzata Roos; Christiane Pauli-Magnus; Gerd Folkers; Peter J. Meier; Karin Fattinger
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 311 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Despite its low incidence, drug-induced liver injury (DILI) continues to have a high impact on the medical community, pharmaceutical industry, and general public. DILI is often difficult to diagnose, and few specific treatments are available. Severe DILI is the primary reason for regulatory actions
Studies of acute liver failure from drugs have included cases mostly attributed to acetaminophen (APAP) but have reported limited data on other drugs. We used the United Network for Organ Sharing (UNOS) liver transplant database from 1990 to 2002 to identify recipients and estimate a U.S. population