Incidence of cancer in Italian ataxia telangiectasia families
β Scribed by L. Chessa; S. Prudente; M. Piane; G. Zei
- Book ID
- 114136681
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 115 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Patients who are homozygous for ataxiaβtelangiectasia (AT) have an exceptionally high incidence of cancer. Heterozygous individuals for the disease have been reported to be at an increased risk of cancer, particularly breast cancer in female carriers. We have analyzed eight Norwegian fa
Ataxia-telangiectasia (A-T) is an autosomal recessive disease involving chromosomal instability, susceptibility to cancer and X-ray hypersensitivity. The latter two features are expressed to a limited extent in the heterozygous carriers of A-T mutations. Although fibroblast lines from A-T heterozygo