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Incidence of abdominal wall defects

✍ Scribed by Robert Roger Lebel

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
81 KB
Volume
19
Category
Article
ISSN
0197-3851

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✦ Synopsis

suggestive of a gastro-intestinal lesion containing echogenic debris. Amniocentesis showed a normal karyotype, no cystic fibrosis mutations (70 analysed) and an AFP of 5.02 MOM. Acetylcholinesterase was weakly positive. 11 days later an intra-uterine demise was diagnosed. A 355 g fetus was delivered showing an imperforate anus and a 50 35 10 mm fluid-filled sac in the large bowel, interpreted as dilated cecum with focal meconium extravasation.

Our results are consistent with those of Chodirker et al. (1994) who found normal MSAFP levels with anal atresis. The mechanism by which MSAFP would be decreased in the presence of anal atresia is unclear. Elevated AFAFP previously has been reported with colon malformation and colon atresia, type unspecified (Crandall and Matsumoto, 1991;Crandall and Chua, 1997), and also with fetal demise. Therefore, our finding of elevated AFAFP might be explained by the subsequent fetal demise rather than by anal atresia.

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