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Incidence of 5′ bcl-2 rearrangement in patients with B cell chronic lymphocytic leukemia from India

✍ Scribed by Purvish M. Parikh; Suvas Desai; K.N. Naresh; Barbhaya Shakuntaka; K. Laxminarayan; C.N. Nair; Mark Ladanyi; C.S. Soman; S.H. Advani; R.S.K. Chaganti


Book ID
113240200
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
249 KB
Volume
20
Category
Article
ISSN
0145-2126

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bcl-2 rearrangement detected by pulsed-f
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B-chronic lymphocytic leukemia (CLL) is characterized by an accumulation of long-lived, resting B cells expressing the Bcl-2 protein. However, less than 10% of the CLL patients shows bcl-2 gene rearrangement in blood cells, using traditional Southern blotting analysis. In the present study, rearrang