Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia
β Scribed by Zhou, M; Gu, L; Abshire, T C; Homans, A; Billett, A L; Yeager, A M; Findley, H W
- Book ID
- 110054403
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 125 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0887-6924
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## Abstract The __TEL/AML1__ rearrangement has been implicated as an independent good prognostic factor in pediatric acute lymphoblastic leukemia (ALL). We examined __TEL/AML1__ using nested reverseβtranscription polymerase chain reaction (RTβPCR) and correlated __TEL/AML1__ with cytogenetics and i
Chromosome studies, using bone marrow samples of 26 pretreated children (below 15 years of age) with Acute Lymphoblastic Leukemia were carried out to explore the potentialities of applying chromosomal findings as a prognostic indicator in these patients. Abnormal karyotype was identified in 15 patie