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Incidence and Mechanisms of Cerebral Ischemia in Early Clinical Head Injury

✍ Scribed by Coles, Jonathan P.; Fryer, Tim D.; Smielewski, Piotr; Chatfield, Doris A.; Steiner, Luzius A.; Johnston, Andrew J.; Downey, Stephen P. M. J.; Williams, Guy B.; Aigbirhio, Franklin; Hutchinson, Peter J.; Rice, Kenneth; Carpenter, T. Adrian; Clark, John C.; Pickard, John D.; Menon, David K.

Book ID
110088647
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
624 KB
Volume
24
Category
Article
ISSN
0271-678X

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## Abstract Citicoline, an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in various CNS injury models and neurodegenerative diseases. PtdCho hydrolysis by phospholipase A~2~ (PLA~2~) after cerebral ischemia and reperfusion yields arachidonic acid (Ar