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Inactivation of the tumor suppressor Krüppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas

✍ Scribed by Xiu-cheng Pan; Zhi Chen; Feng Chen; Xiao-hong Chen; Han-yin Jin; Xiao-yan Xu


Book ID
111840558
Publisher
SP Zhejiang University Press
Year
2006
Tongue
English
Weight
652 KB
Volume
7
Category
Article
ISSN
1673-1581

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Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, reflecting incomplete characterization of underlying mechanisms and lack of early detection. Kru ¨ppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcription factor that is deregulated in multiple cancer