Inactivation of the Rb gene in human cancer
- Book ID
- 122046635
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 178 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0169-5002
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## Abstract Reduced expression of the retinoblastoma gene (RB)2/p130 protein, as well as mutation of exons 19, 20, 21, and 22 of the same gene, has been reported in primary lung cancer. However, it has been suggested by other investigators that mutational inactivation and loss of the __RB2__/__p130
## Abstract Lipoprotein lipase (__LPL__) is in chromosome 8p22, site of one of the most common somatic deletions in prostate tumors. Additionally, a CpG island (CGI) was identified in the __LPL__ promoter region. To test the hypothesis that __LPL__ is a tumor suppressor gene, which is inactivated b
## Abstract Inactivation of tumor suppressor protein retinoblastoma (Rb) is important mechanism for the G~1~/S transition during cell cycle progression. Human breast cancer cells T47D release great amount of nitric oxide (NO), but its relation to tumor suppressor Rb is unknown. In this study, it is