Inactivation of the p16 gene in human pituitary nonfunctioning tumors by hypermethylation is more common in null cell adenomas

Frequent inactivation of the p16 gene in

Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation

✍ Michael Woloschak; Aiqin Yu; Kalmon D. Post 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 2 views

Rodent models of pituitary tumorigenesis have implicated the retinoblastoma (Rb) pathway in the development of pituitary tumors. Previously, we reported that loss of p16 expression rather than loss of Rb occurs in most human pituitary adenomas. This alteration in these tumors is not associated with