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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

✍ Scribed by Van der Ploeg, Lex H.T.; Chen, Airu S.; Marsh, Donald J.; Trumbauer, Myrna E.; Frazier, Easter G.; Guan, Xiao-Ming; Yu, Hong; Rosenblum, Charles I.; Vongs, Aurawan; Feng, Yue; Cao, Linhai; Metzger, Joseph M.; Strack, Alison M.; Camacho, Ramon E.; Mellin, Theodore N.; Nunes, Christian N.; Min, William; Fisher, Jill; Gopal-Truter, Shobhna; MacIntyre, D. Euan; Chen, Howard Y.

Book ID: 109828895
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 341 KB
Volume: 26
Category: Article
ISSN: 1061-4036
DOI: 10.1038/79254

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## Background Cachexia, also known as muscle wasting, is a complex metabolic condition characterized by loss of skeletal muscle and a decline in physical function. Muscle wasting is associated with cancer, sarcopenia, chronic obstructive pulmonary disease, end-stage renal disease, and other chronic