The FHIT (fragile histidine triad) gene has been isolated from the chromosome region 3p14.2, which includes the fragile site locus FRA3B and the breakpoint of the t(3;8) of familial renal carcinoma. FHIT has been suggested to be a candidate tumor suppressor gene for digestive tract carcinomas. To ev
Inactivation of the E-Cadherin Gene in Primary Gastric Carcinomas and Gastric Carcinoma Cell Lines
β Scribed by Tamura, Gen ;Sakata, Ken ;Nishizuka, Satoshi ;Maesawa, Chihaya ;Suzuki, Yasushi ;Iwaya, Takeshi ;Terashima, Masanori ;Saito, Kazuyoshi ;Satodate, Ryoichi
- Book ID
- 108581294
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1996
- Tongue
- English
- Weight
- 479 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0910-5050
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Hepatocyte growth factor (HGF), identical to scatter factor, (SF) is a secretory glycoprotein from fibroblasts which dissociates and increases the motility of various types of epithelial cells. After treatment of three gastric carcinoma cell lines (MKN-28, MKN-45 and TMK-1) with HGF (10 ng/ml), TMK-
CpG methylation in the promoter region has been shown to be important in the regulation of genes implicated in malignant transformation. The present study was designed to test the hypothesis that CpG methylation of the promoter region of the E-cadherin gene may inactivate its expression in renal cel