## Abstract ## Background and Objectives Low tumor expression of the p27^Kip1^ protein, which is involved in cell cycle control and apoptosis, is considered a negative prognostic factor in different types of cancer. The aim of this study was to evaluate the clinical and pathological significance o
Inactivation of PTEN is associated with a low p27Kip1 protein expression in breast carcinoma
β Scribed by Shinichi Tsutsui; Hiroshi Inoue; Kazuhiro Yasuda; Kosuke Suzuki; Kouichirou Tahara; Hidefumi Higashi; Shoichi Era; Masaki Mori
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 90 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0008-543X
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Background and Objectives: p27Kip1 is an inhibitor of cyclindependent kinases and is speculated to be a potential prognostic indicator in numerous human cancers. We investigated expression of p27Kip1 along with cyclin D1 in gastric cancer to estimate the clinical utility of p27Kip1. Methods: Immunoh
## BACKGROUND. Low expression of p27 kip1 , a dominant cyclin-dependent kinase inhibitor involved in G1-S transition of the cell cycle, recently has been reported to be associated with aggressive tumor growth. It has been shown that active cell proliferation alludes to poor prognosis in patients w
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