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Inactivation of pig heart alanine aminotransferase by β-chloroalanine

✍ Scribed by Alan Golichowski; W.Terry Jenkins

Book ID
115703634
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
499 KB
Volume
189
Category
Article
ISSN
0003-9861

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Inactivation of γ-aminobutyric acid amin
Inactivation of γ-aminobutyric acid aminotransferase by l-3-chloroalanine hydroxamate
✍ Richard B. Silverman; Gregory T. Olson 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 652 KB

The mechanism of inactivation of gamma-aminobutyric acid aminotransferase (GABA-AT) by L-3-chloroalanine hydroxamate (1) was investigated. Inactivation of [3H]PLP-reconstituted GABA-AT with 1 followed by denaturation gave no PMP or enamine adduct to the PLP; however, a new unknown metabolite was obs