Inactivation of peroxisome proliferator-activated receptor isoforms α, β/δ, and γ mediate distinct facets of hypertrophic transformation of adult cardiac myocytes

Cytosolic phospholipase A2α and peroxiso

Cytosolic phospholipase A2α and peroxisome proliferator-activated receptor γ signaling pathway counteracts transforming growth factor β–mediated inhibition of primary and transformed hepatocyte growth

✍ Chang Han; William C. Bowen; Guiying Li; Anthony J. Demetris; George K. Michalop 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 735 KB

Hepatocellular carcinoma often develops in the setting of abnormal hepatocyte growth associated with chronic hepatitis and liver cirrhosis. Transforming growth factor b (TGFb) is a multifunctional cytokine pivotal in the regulation of hepatic cell growth, differentiation, migration, extracellular ma