Inactivation of O6-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations
β Scribed by Jeung Il Kim; Jeung Tak Suh; Kyung Un Choi; Hyun Jeong Kang; Dong Hoon Shin; In Sook Lee; Tae Yong Moon; Won Taek Kim
- Book ID
- 116534674
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 443 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1532-8392
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## Abstract The DNA repair enzyme O^6^βmethylguanineβDNA methyltransferase (MGMT) removes alkylating adducts from the O^6^ position of guanine and protects cells from cytotoxic and mutagenic effects. Expression of __MGMT__ is decreased in some cancers, which may be the result of methylation of CpG
## Abstract O^6^βmethylguanineβDNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylationβspecific PCR (MSP)