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Inactivation of N-terminal signaling domain of Sonic hedgehog by forming a disulfide bond

โœ Scribed by Kazuko Saeki; Mieko Katsuura; Sachiko Yanagisawa; Ryosuke Suzuki; Makoto Okazaki; Michio Kimura


Book ID
114150106
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
570 KB
Volume
1476
Category
Article
ISSN
0167-4838

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## Abstract The signaling domain of Sonic hedgehog (Shh), a potent upstream regulator of cell fate that has been implicated in osteoblast differentiation from undifferentiated mesenchymal cells in its endogenous form, was investigated in an immobilized form as a means for accelerating differentiati