Inactivation of human plasma proteinase inhibitors by snake venom proteinases: Lawrence F. Kress and T. Kurecki Roswell Park Mem. Inst., Buffalo, N.Y. 14263

Inactivation of human plasma serine prot

Inactivation of human plasma serine proteinase inhibitors (serpins) by limited proteolysis of the reactive site loop with snake venom and bacterial metalloproteinases

✍ Lawrence F. Kress 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 519 KB

Human plasma serine proteinase inhibitors (serpins) gradually lost activity when incubated with catalytic amounts of snake venom or bacterialmetalloproteinases. Electrophoretic analyses indicated that antithrombin 111, C l-inhibitor, and 012antiplasmin had been converted by limited proteolysis into