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Inactivation of glycogen synthase kinase-3β up-regulates β-catenin and promotes chondrogenesis

✍ Scribed by Zhou, Junjie; Chen, Yan; Cao, Chengfu; Chen, Xianqi; Gao, Wenwu; Zhang, Lei

Book ID
125357497
Publisher
Springer
Year
2014
Tongue
English
Weight
924 KB
Volume
16
Category
Article
ISSN
1389-9333

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## Abstract Overexpression of ΔNp63 has been observed in a number of human cancers, suggesting a role for ΔNp63 in carcinogenesis. In the present study, we show that inhibition of glycogen synthase kinase‐3β (GSK‐3β) by lithium chloride (LiCl) elicited a stimulatory effect on ΔNp63 promoter activit