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Inability of a reserpine-based screen to identify strains overexpressing efflux pump genes in clinical isolates of Staphylococcus aureus

โœ Scribed by Emmanuel Frempong-Manso; Jose L. Raygada; Carmen E. DeMarco; Susan M. Seo; Glenn W. Kaatz

Book ID
119260094
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
117 KB
Volume
33
Category
Article
ISSN
0924-8579

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The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant
โœ Simon Gibbons; E. E. Udo ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 37 KB ๐Ÿ‘ 2 views

As part of a screening programme to identify modulators of multidrug efflux in methicillin resistant Staphyloccocus aureus (MRSA), we have validated our assays using the antihypertensive plant alkaloid reserpine. Clinical isolates of MRSA were resistant to tetracycline and shown to possess the tet(K