In vivo/in vitro correlations of nitrofurantoin matrix tablet formulations
✍ Scribed by H. Y. Karasulu; G. Ertan; T. Köse; T. Günerí
- Book ID
- 113006847
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 555 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0378-7966
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Four experimental controlled-release oral solid dosage formulations were developed and the in vitro dissolution characteristics of theophylline from these formulations were studied in USP apparatus I. Pharmacokinetic evaluation of these formulations was carried out in eight beagle dogs under fasting
Four 50 mg and three 100 mg marketed nitrofurantoin tablets were studied in 14 healthy male subjects. Urine was collected 1, 2, 3, 4, 6, 8, 12, and 23 h after each dose, and nitrofurantoin was assayed by HPLC. The in vitro dissolution of the tablets was determined using USP Apparatus 1 and 2, with 0