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In vivo123I IBZM SPECT imaging of striatal dopamine 2 receptor occupancy in schizophrenic patients

✍ Scribed by Christian Barnas; Sylvia Quiner; Johannes Tauscher; Eva Hilger; Matthäus Willeit; Bernd Küfferle; Susanne Asenbaum; Thomas Brücke; Marie-Luise Rao; Siegfried Kasper


Publisher
Springer
Year
2001
Tongue
English
Weight
172 KB
Volume
157
Category
Article
ISSN
0033-3158

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Binding competition between endogenous dopamine (DA) and the D 2 receptor radiotracer [ 123 I]IBZM allows measurement of the change in synaptic DA following amphetamine challenge with SPECT in the living human brain. Previous investigations using this technique in healthy subjects have shown that th