In vivo venous blood T1 measurement using inversion recovery true-FISP in children and adults
✍ Scribed by Wen-Chau Wu; Varsha Jain; Cheng Li; Mariel Giannetta; Hallam Hurt; Felix W. Wehrli; Danny J. J. Wang
- Book ID
- 102955502
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 773 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
A time‐efficient method is described for in vivo venous blood T~1~ measurement using multiphase inversion‐recovery‐prepared balanced steady‐state free precession imaging. Computer simulations and validation experiments using a flow phantom were carried out to demonstrate the accuracy of the proposed method for measuring blood T~1~ by taking advantage of the continuous inflow of fresh blood with longitudinal magnetization undisturbed by previous radiofrequency pulses. In vivo measurement of venous blood T~1~ in the sagittal sinus was carried out in 26 healthy children and adults aged 7–39 years. The measured venous blood T~1~ values decreased with age as a whole (P = 0.006) and were higher in females than males (P = 0.013), matching the expected developmental changes and gender differences in human hematocrit level. The estimated mean blood T~1~ values were highly correlated with normal hematocrit levels across age and gender groups (Spearman's r = 0.93, P = 0.008). The longitudinal repeatability of this technique was 4.0% as measured by the within‐subject coefficient of variation. The proposed multiphase inversion recovery‐prepared balanced steady‐state free precession imaging method is a feasible technique for fast (<1 min) and reliable in vivo venous blood T~1~ measurement and may serve as an index of hematocrit level in individual subjects. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.