In vivo testing of crosslinked polyethers. II. Weight loss, IR analysis, and swelling behavior after implantation
✍ Scribed by Pol, B. J. M. ;van der Does, L. ;Bantjes, A. ;van Wachem, P. B.
- Book ID
- 102654211
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 1020 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
As reported in Part I ("In vivo testing of crosslinked polyethers. I. Tissue reactions and biodegradation," J. Biomed. Muter. Res., this issue,, microscopical evaluation after implantation of crosslinked (co)polyethers in rats showed differences in the rate of biodegradation, depending on the presence of tertiary hydrogen atoms in the main chain and the hydrophilicity of the polyether system. In this article (Part 11) the biostability will be discussed in terms of weight loss, the swelling behavior, and changes in the chemical structure of the crosslinked polyethers after implantation. The biostability increased in the order poly(P0x) < poly(THF-co-OX) < poly(THF) for the relatively hydropho-bic polyethers. This confirmed our hypothesis that the absence of tertiary hydrogen atoms would improve the biostability. On the other hand, signs of biodegradation were observed for all polyether system studied. Infrared surface analysis showed that biodegradation was triggered by oxidative attack on the polymeric chain, leading to the formation of carboxylic ester and acid groups. It also was found that in the THF-based (co)polyethers, a-methyiene groups were more sensitive than P-methylene groups. For a hydrophilic poly(THF)/PEO blend, an increase in surface PEO content was found, which might be due to preferential degradation of the PEO domains.