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In vivo suppression of T-dependent antibody responses by treatment with a monoclonal anti-L3T4 antibody

✍ Scribed by Pierre G. Coulie; Jean-Paul Coutelier; Catherine Uyttenhove; Paul Lambotte; Jacques Van Snick

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 347 KB
Volume: 15
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830150620

No coin nor oath required. For personal study only.

✦ Synopsis

Minute amounts of the anti-L3T4 antibody designated GK1.5 were found to deeply suppress in vivo antibody responses to T-dependent antigens. Primary responses to sheep erythrocytes were completely inhibited even when GK1.5 was administered up to 6 days before or 4 days after the antigen. Secondary responses to potent immunogens like sheep erythrocytes or keyhole limpet hemocyanin were also completely abolished by a single injection of GK1.5 just before the boost. This treatment had no effect on T-independent reactions such as the polyclonal activation of B lymphocytes with lipopolysaccharide or the anti-2,4,6-trinitrophenyl (TNP) response elicited by injection of TNP-Ficoll.

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