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In vivo study effect of particulate Bioglass® in the prevention of infection in open fracture fixation

✍ Scribed by Zong-Ping Xie; Chang-Qing Zhang; Cheng-Qing Yi; Jian-Jun Qiu; Jian-Qiang Wang; Juan Zhou

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
238 KB
Volume
90B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

There are many in vitro experiments showing that particulate bioactive glasses have a broad and certain antibacterial effect, but there is no report about this antibacterial effect in vivo so far. The aim of this study is to examine the efficacy of particulate Bioglass® in reducing the rate of infection with Staphylococcus aureus after the fixation of open tibial fractures in rabbits. The test in vivo was carried out with male rabbits split into two groups infected with Staphylococcus aureus at the right tibial fracture sites fixed with plate and screw, either with or without bioactive glass respectively. Culture results show that six of ten rabbits from the control group had a positive culture for the strain of Staphylococcus aureus ATCC25923, compared with six of the nine rabbits from the Bioglass® group. The median radiographic score is 4.5 points for the rabbits from the control group and 4 points for the rabbits from the Bioglass® group. The median histopathological score was 2.5 points for the rabbits in the control group and 3 points for the rabbits in the Bioglass® group. In conclusion, this study showed no significant difference between the rates of infection of two groups. Particulate Bioglass® did not reduce the rate of infection with Staphylococcus aureus after the fixation of open tibial fractures in rabbits. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009

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