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In vivo somatic delivery of plasmid DNA and retrograde transport to obtain cell-specific gene expression in the central nervous system

✍ Scribed by Renée Morris; Branwen S. Morgan; Trevor M. Lewis; Kerrie D. Pierce; Anthony Pisano; Peter R. Schofield

Book ID: 111178399
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 209 KB
Volume: 90
Category: Article
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2004.02612.x

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## Abstract ## Background In previous studies, we showed that gene activated matrices (GAMs) containing nonviral vectors successfully deliver genes to neurons after optic nerve and spinal cord injury. In the present study, we evaluated whether adenoviral vectors delivered within a GAM increase the