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In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes

✍ Scribed by Kissler, Stephan; Stern, Patrick; Takahashi, Kazue; Hunter, Kara; Peterson, Laurence B; Wicker, Linda S


Book ID
109919338
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
264 KB
Volume
38
Category
Article
ISSN
1061-4036

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Genes in the HLA complex are by far the most important in determining genetic predisposition or resistance to Type 1 (insulin-dependent) diabetes mellitus. In this review evidence is presented that the HLA genes mainly involved are those encoding some particular HLA-DQ molecules. Both among Black, C